Selected Publications

  • Chapman, P. B., A. Hauschild, C. Robert, J. B. Haanen, P. Ascierto, J. Larkin, R. Dummer, C. Garbe, A. Testori, M. Maio, D. Hogg, P. Lorigan, C. Lebbe, T. Jouary, D. Schadendorf, A. Ribas, S.J. O’Day, J. A. Sosman, J.M. Kirkwood, A. M. Eggermont, B. Dreno, K. Nolop, J. Li, B. Nelson, J. Hou, R. J. Lee, K. T. Flaherty, A. G. McArthur (2011): BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 364(26):2507–16.
  • Dietze, K.K., G. Zelinskyy, K. Gibbert, S. Schimmer, S. Francois, L. Myers, T. Sparwasser, K.J. Hasenkrug, U. Dittmer (2011): Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A. 108(6):2420–5.
  • Ehrentraut, S., M. Hassler, M. Oppikofer, S. Kueng, J. M. Weber, J.W. Mueller, S.M. Gasser, A. G. Ladurner, A. E. Ehrenhofer-Murray (2011): Structural basis for the role of the Sir3 AAA+ domain in silencing: Interaction with Sir4 and unmethylated histone H3K79. Genes Dev 25 (17).
  • Eyking, A., B. Ey, M.Rünzi, Al. Roig, H. Reis, H. W. Schmid, G. Gerken, D. K. Podolsky, E. Cario (2011): Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer. Gastroenterology. 
  • Lättig-Tünnemann, G., M. Prinz, D. Hoffmann, J. Behlke, C. Palm-Apergi, I. Morano, H. D. Herce, M. C. Cardoso (2011): Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides. Nat. Commun. 2:453.
  • Meerang, M., D. Ritz, S. Paliwal, Z. Garajova, M. Bosshard, N. Mailand, P. Janscak, U. Hübscher, H. Meyer, K. Ramadan (2011): The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat. Cell Biol.
  • Meyer, C., A. Sevko, M. Ramacher, A. V. Bazhin, C. S. Falk, W. Osen, I. Borrello, M. Kato, D. Schadendorf, M. Baniyash, V. Umansky (2011): Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model. Proc Natl Acad Sci U S A. 108(41):17111–6.
  • Ritz, D., M. Vuk, P. Kirchner, M. Bug, S. Schütz, A. Hayer, S. Bremer, C. Lusk, R. H. Baloh, H. Lee, T. Glatter, M. Gstaiger, R. Aebersold, C. C. Weihl, H. Meyer (2011): Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol.
  • Trübestein, L., A. Tennstaedt, T. Mönig, T. Krojer, F. Canellas, M. Kaiser, T. Clausen, M. Ehrmann (2011): Substrate induces remodeling of the active site regulates human HtrA1 activity. Nat. Struct. Mol. Biol. 18:386–388.
  • Zhang, Y., X. Li, A. Carpinteiro, J.A. Goettel, M. Soddemann, E. Gulbins (2011): Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat. Med. 17(3):341–6. Epub 2011 Feb 6.